An Introduction to Pathways for Skin Penetration
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Who Should Attend
This overview, introductory online course is intended for individuals who are interested in obtaining basic knowledge in recent findings about the
skin as a barrier, possible ways of interaction between the skin and applied compounds and patterns and pathways for penetration into and
through the skin. Attendees may hold a function in the following areas:
• Skin research and development
• Formulation chemistry
• Toxicology and regulatory affairs
• Technical sales and marketing
Description
This 90-minute accredited online training is tailored for individuals who want to gain better understanding in the detailed structure of the skin and
the correlation between structure and penetration. Participants will be introduced to the biochemistry of the upper layer of the skin, the stratum
corneum, and the different theories about pathways of penetration through it. The session will provide basic tools for understanding the
limitations in penetration and will suggest possible ways to overcome the skin barrier. It will discuss testing models as well as considerations to
be taken such as skin age and condition.
Module 1:
• Skin structure
• The stratum corneum
• The living epidermis
• The intercellular lipids
• The role of ceramides
Module 2:
• Gradients in the skin and their possible role
in partitioning
• The water gradient; pH gradient; lipid
gradient
• The role of pilosebaceus glands in skin
penetration
• Sebum composition; Sebum flow
• Pore size
• Models for pore penetration
• The polar/pore pathway
Module 3:
• In vitro models for skin penetration
• In vivo models for skin penetration
• Chemical skin permeation enhancers
• Vesicular skin permeation enhancers
Question and Answer Session
Summary