Developability Assessment
This course is not currently scheduled. Click on the Notify Me button to the left to be notified when it is scheduled.
This course is available as a client site course. Please click here for more information.
Who Should Attend
This course is specifically designed for personnel in the
pharmaceutical and biotechnology industries and contract
research organizations (CROs) who are involved in drug
discovery and early drug development and who want to
have a better understanding of the approaches and
techniques available for discovery lead selection and
optimization. Participants should have some knowledge of
drug discovery and development and desire to learn more
about how to logically design, conduct, and interpret lead
optimization experiments in order the select the optimal
compound for preclinical development. Drug discovery and
development scientists, managers, and project team
leaders will gain a detailed understanding of the types of
developability assessment research studies that can be
conducted to determine the drug-like attributes and
potential demerits of a discovery lead or group of leads.
Description
The content of this course will assist pharmaceutical,
biotechnology, and CRO researchers and managers in
understanding the requirements for a logical, well designed,
and successful developability assessment program. The
various types of lead optimization experiments, which
include in vitro
and in vivo pharmacology, stability and
solubility assessments, in vitro
drug metabolism and
delivery, preliminary animal pharmacokinetics, and in vitro
and acute toxicology, will be described and discussed.
Study designs and potential results, with possible
interpretations, from each of the study types will be
presented. Examples of developability assessment logic
plans for various types of drug discovery programs will be
presented and a workshop will provide participants with the
opportunity to design and discuss other logic plan types.