Pharmacokinetics—ADME Fundamentals
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Who Should Attend
This course is designed for a broad range of personnel in the
pharmaceutical and medical device industries that need a
basic understanding of ADME/pharmacokinetics, especially
as it pertains to drug and device development. It should be
especially valuable for:
• Those needing a basic understanding of the processes
involved in absorption, disposition, metabolism and
elimination of drugs
• Managers of pharmacology and toxicology studies
• Scientists that direct or evaluate pre-clinical studies
• Chemists, engineers and other scientists involved in drug
and device development
• Biomedical engineers
Description
This intensive, 3-day course will provide participants with an
understanding of the principals and fundamentals for
absorption, distribution, metabolism, and the elimination
(ADME) of exogenous molecules and pharmacokinetics
parameters used to describe these as well as basic concepts
in modeling. The actual dose of a drug that ultimately reaches
the target tissues and exerts pharmacologic or toxicologic
effects is highly dependent on the kinetics of drug absorption
and disposition in the body. Many factors can influence these
kinetic processes. The goal of the course is to provide training
in the fundamentals of ADME that should be understood for
those involved in drug development and clinical applications.
The thrust of the discussions will pertain to drugs, although the
concepts are appropriate for all chemical entities. Some
modeling and mathematical formulations will be presented;
however, the lack of mathematical background will not impede
one’s ability to understand the concepts involved. Practical
examples of the ADME of problems for drugs and potential
solutions to them will be provided to illustrate the application of
principles in real life situations.