ADME Fundamentals
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Who Should Attend
This course is designed for a broad range of personnel in the
pharmaceutical industry that need a basic understanding of
ADME/pharmacokinetics, especially as it pertains to drug
development. It should be especially valuable for:-
Those needing a basic understanding of the processes
involved in absorption and disposition of drugs
- Managers of pharmacology and toxicology studies
- Scientists that direct or evaluate pre-clinical studies
- Chemists and other scientists involved in drug development
- Biomedical engineers
Description
The course will provide participants with an understanding of
the principals and fundamentals for absorption, distribution,
metabolism, and the elimination (ADME) of pharmaceutical
chemicals. The actual dose of a drug that ultimately reaches
the target tissues and exerts pharmacologic or toxicologic
effects is highly dependent on the kinetics of drug absorption
and disposition in the body. Many factors can influence these
kinetic processes. The goal of the course is to provide training
in the fundamentals of ADME that should be understood for
those involved in drug development and clinical applications.
The thrust of the discussions will pertain to drugs, although
the concepts are appropriate for all chemical entities. Some
modeling and mathematical formulations will be presented;
however, the lack of mathematical background will not impede
one’s ability to understand the concepts involved. Finally, a few
practical examples of the ADME of drugs will be provided to
illustrate how the principles are applied in real life situations.