Course offering number:1010-303
Course ID:
279
Lyophilization Technology
October 12-14, 2010
New Brunswick, NJ
Who Should Attend
This course is designed for personnel in the pharmaceutical,
diagnostic, biomedical engineering and biotechnology
industries responsible for the specification, development and
production of lyophilized products, including:
• Biochemists
• R & D Personnel
• Chemists
• Pilot Plant Operations
• Chemical Engineers
• Production Supervisors
• Microbiologists
• Managers
• Pharmacists
• QA/QC
Those new to the industry and those with previous
experience will find the course beneficial.
Description
This course is designed to provide participants with an
up-to-date understanding of the theory and practice of
lyophilization. Freeze-drying (lyophilization) will be presented
and explained in physical, physicochemical, biochemical and
engineering terms. Theory and practice will be interrelated
and biotechnological and pharmaceutical applications will be
emphasized. Participants should acquire a comprehension
that transcends common disciplinary boundaries.
Topics covered will include vacuum physics, properties of
water and ice, supercooling and supersaturation, phase
behavior during freezing, differential thermal analysis, electrical
resistance, glassy state behavior, collapse phenomena,
desorption phenomena, product formulation, heat and mass
transfer, development of freeze-drying cycles, end point
determination, residual moisture, product stability, process
scale-up, process control and optimization, Current Good
Manufacturing Practice (cGMP), and validation. Fault finding
and problem solving will be presented using case studies.