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Course offering number:0803-702

Course ID:
2202
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Guidelines to In Vitro Skin Absorption Studies
Pre-recorded Course
AN ON-DEMAND ONLINE TRAINING FORMAT

Who Should Attend
Skin absorption studies are part of various international regulatory requirements for safety assessment of exposure to chemicals. For topically applied formulations, when the skin is the target of action, assessment of penetration can allow for better product design. In vitro skin absorption studies were shown as a reliable way to evaluate penetration of compounds into and through the skin. The course will be beneficial to professionals in the pharmaceutical and cosmetic industries, especially those who are involved in the following areas:

  • Skin research and development
  • Formulation chemistry
  • Toxicology and regulatory affairs
  • Technical sales and marketing

Description
This 90-minute course will explain the importance of evaluating skin absorption of compounds from topically applied formulations for safety assessment, mechanistic studies and prior to conducting clinical studies.

Module 1:

  • Rationale for assessment of skin penetration
  • Regulatory parties involved:
    – OECD
    – CTFA
    – WHO
  • Description of general procedure


  • Module 2:
  • Preliminary required physical chemical properties
  • Types of diffusion cells
  • Finite and infinite dosing
  • Importance of vehicle applied
  • Fick’s first law for simple diffusion


  • Module 3:
  • Skin preparation:
    – Choice of skin
    – Species differences
    – Preparation of tissue samples:
    – Full thickness skin
    – Epidermal skin
    – Stratum corneum
  • Testing skin barrier integrity
  • Application of test compound
  • Receptor fluid
  • Evaluation of results
  • Summary



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