Course offering number:0803-702
Course ID:
2202
Guidelines to In Vitro Skin Absorption Studies
Pre-recorded Course
AN ON-DEMAND ONLINE TRAINING FORMAT
Who Should Attend
Skin absorption studies are part of various international regulatory requirements for safety assessment of exposure to
chemicals. For topically applied formulations, when the skin is the target of action, assessment of penetration can allow
for better product design. In vitro skin absorption studies were shown as a reliable way to evaluate penetration of
compounds into and through the skin.
The course will be beneficial to professionals in the pharmaceutical and cosmetic industries, especially those who are
involved in the following areas:-
Skin research and development
- Formulation chemistry
- Toxicology and regulatory affairs
- Technical sales and marketing
Description
This 90-minute course will explain the importance of evaluating skin absorption of compounds from topically applied formulations for safety assessment and mechanistic studies prior to conducting clinical studies.
Module 1:
Rationale for assessment of skin penetration
Regulatory parties involved:
– OECD
– CTFA
– WHO
Description of general procedure
Module 2:
Preliminary required physical chemical properties
Types of diffusion cells
Finite and infinite dosing
Importance of vehicle applied
Fick’s first law for simple diffusion
Module 3:
Skin preparation:
– Choice of skin
– Species differences
– Preparation of tissue samples:
– Full thickness skin
– Epidermal skin
– Stratum corneum
Testing skin barrier integrity
Application of test compound
Receptor fluid
Evaluation of results
Summary